This 2013 review, published in the journal Brain Sciences, focused on numerous experimental studies. They report that the modulation of the endocannabinoid system either by enhancement of the endogenous cannabinoid signaling or by administration of exogenous cannabinergic ligands has beneficial effects during the acute and recovery phases after perinatal brain injury.
Medical Cannabis Research
This 2014 study published in Lancet Psychiatry recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high school completion and degree attainment and substantially increased odds of later cannabis dependence, use of other illicit drugs, and suicide attempt.
Osteoarthritis and cannabis – Information comes from scientists in the UK and USA, published in PLOS ONE in 2013. Osteoarthritis pain is challenging to treat, with chronic pain leading to central sensitization. Cannabinoids can help. This data provides new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits central sensitization and its contribution to the manifestation of chronic OA pain. These findings suggest that targeting CB2 receptors may have therapeutic potential for treating OA pain.
Endocannabinoid Anandamide and breast cancer – more evidence. This 2014 study out of Italy, published in the journal Translational Medicine, found that following anandamide treatment, MDA-MB-231 cells lose their ability to stimulate endothelial cells proliferation in vitro, due to a significant inhibition of all the pro-angiogenic factors produced by these cells. This finding adds another piece of evidence to the anti-tumor efficacy of anandamide in breast cancer.
THC and breast cancer – Little is known about the effect of cannabinoids on the cell cycle, the main process controlling cell fate. This study out of Spain, published in a 2006 issue of Cancer Research, shows that Δ9-tetrahydrocannabinol (THC), through activation of CB2 cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis
As reported in the August, 2014 issue of JAMA Internal Medicine, this research shares an examination of the association between medical cannabis laws and opioid analgesic overdose mortality. Each year after implementation of the law showed that such laws were associated with a lower rate of overdose mortality that generally strengthened over time.