Medical Cannabis Research

Psychosis And High Potency Cannabis

Psychosis And High Potency Cannabis - 2015 Study
Published in the February 2015 issue of Lancet Psychiatry is this study looking at psychosis linked to use of potent cannabis. The risk of individuals having a psychotic disorder showed a roughly three-times increase in users of skunk-like cannabis compared with those who never used cannabis. The lack of cannabidiol (CBD) in skunk may be a contributing factor.

 

Cannabinoid CB2 Receptors in Brain Reward Systems

Cannabinoid CB2 Receptors in Brain Reward Systems
In this study, published in November 2014, Zhang and fellow researchers located CB2 receptors and their genes in dopaminergic neurons in a brain area that is involved in reward and drug addiction. Distinct from CB1 receptors, CB2 receptors have been long associated with immune cell function. Activation of these receptors in the brain caused a reduction in cocaine self-administration by mice, suggesting a role for these receptors in modulating reward from cocaine.

 

Endocannabinoids and Prostate Cancer

Endocannabinoids and Prostate Cancer
This study, published in the January 2015 issue of Oncology Reports, concludes that endocannabinoids are capable of halting the growth of prostate cancer cells through activation of apoptotic mecha­nisms.

 

Dr. O’Shaughnessy’s Pain Preparation

Dr. O'Shaughnessy's Pain Preparation
From an 1843 issue of the Provincial Medical Journal in London, comes this reprint of Dr. William O’Shaughnessy’s report on preparation of hemp in the treatment of pain. “As to the evil sequels so unanimously dwelt on by all writers, these did not appear to me so numerous, so immediate, or so formidable, as many which may be clearly traced to over-indulgence in other powerful stimulants or narcotics-viz, alcohol, opium, or tobacco.”.

 

Medical Marijuana Laws and Suicide

Medical Marijuana Laws and Suicide
Published in the January, 2015 issue of Research Briefs in Economic Policy is a study on medical marijuana laws and suicide rates. This research suggests the public-health benefits of legaliza­tion may outweigh the costs.
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Cannabinoid Receptors and Huntington’s Disease

Cannabinoid Receptors and Huntington's Disease
A 2010 study in the journal Brain shares results that support the notion that downregulation of type 1 cannabinoid receptors is a key pathogenic event in Huntington’s disease, and suggest that activation of these receptors in patients with Huntington’s disease may attenuate disease progression.

 

The Endocannabinoid System and Brain Aging

The Endocannabinoid System and Brain Aging
Published in 2012, this study concluded that elevation of cannabinoid receptor activity either by pharmacological blockade of the degradation of cannabinoids or by receptor agonists could be a promising strategy for slowing down the progression of brain aging and for alleviating the symptoms of neurodegenerative disorders.

 

Perinatal Brain Injury

Perinatal Brain InjuryThis 2013 review, published in the journal Brain Sciences, focused on numerous experimental studies. They report that the modulation of the endocannabinoid system either by enhancement of the endogenous cannabinoid signaling or by administration of exogenous cannabinergic ligands has beneficial effects during the acute and recovery phases after perinatal brain injury.

 

Adolescents and Cannabis

Adolescents and CannabisThis 2014 study published in Lancet Psychiatry recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high school completion and degree attainment and substantially increased odds of later cannabis dependence, use of other illicit drugs, and suicide attempt.