Medical Cannabis Research

Cannabidiol Dose-Response

Cannabidiol Dose-Response
CBD gives a bell-shaped dose-response curve. Healing is only observed when CBD is given within a very limited dose range, whereas no beneficial effect is achieved at either lower or higher doses. This trait of purified CBD imposes serious obstacles in planning human and animal studies. The aim of this study was to find a CBD source that could eliminate the bell-shaped dose-response of purified CBD. They found that by using standardized plant extracts from the Cannabis clone 202 obtained from Tikun Olam, Israel, which is highly enriched in CBD and barely contains THC, a correlative anti-inflammatory and anti-pain dose-response could be achieved.

Pregnenolone and Cannabis Intoxication

Pregnenolone And Cannabis Intoxication
Pregnenolone, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation.

Effects of Chronic Cannabis Use in the Compassionate Investigational New Drug Program

Effects of Chronic Cannabis Use
The Missoula Chronic Clinical Cannabis Use Study was published in 2002. This project, with Ethan Russo as lead author, provided the first opportunity to scrutinize the long-term effects of cannabis on patients who had used a known dosage of a standardized, heat-sterilized quality-controlled supply of low-grade marijuana for 11 to 27 years.

Effects of Long Term Cannabis Use

Effects Of Long Term Cannabis Use
In a 2003 issue of the Journal of International Neuropsychological Society is this study looking at the possible long-term residual effects of using cannabis. The results of this meta-analytic study failed to reveal a substantial, systematic effect of long-term, regular cannabis consumption on the neurocognitive functioning of users who were not acutely intoxicated.

Psychosis and High Potency Cannabis

Psychosis and High Potency Cannabis - 2015 Study
Published in the February 2015 issue of Lancet Psychiatry is this study looking at psychosis linked to use of potent cannabis. The risk of individuals having a psychotic disorder showed a roughly three-times increase in users of skunk-like cannabis compared with those who never used cannabis. The lack of cannabidiol (CBD) in skunk may be a contributing factor.


Cannabinoid CB2 Receptors in Brain Reward Systems

Cannabinoid CB2 Receptors in Brain Reward Systems
In this study, published in November 2014, Zhang and fellow researchers located CB2 receptors and their genes in dopaminergic neurons in a brain area that is involved in reward and drug addiction. Distinct from CB1 receptors, CB2 receptors have been long associated with immune cell function. Activation of these receptors in the brain caused a reduction in cocaine self-administration by mice, suggesting a role for these receptors in modulating reward from cocaine.


Endocannabinoids and Prostate Cancer

Endocannabinoids and Prostate Cancer
This study, published in the January 2015 issue of Oncology Reports, concludes that endocannabinoids are capable of halting the growth of prostate cancer cells through activation of apoptotic mecha­nisms.


Dr. O’Shaughnessy’s Pain Preparation

Dr. O'Shaughnessy's Pain Preparation
From an 1843 issue of the Provincial Medical Journal in London, comes this reprint of Dr. William O’Shaughnessy’s report on preparation of hemp in the treatment of pain. “As to the evil sequels so unanimously dwelt on by all writers, these did not appear to me so numerous, so immediate, or so formidable, as many which may be clearly traced to over-indulgence in other powerful stimulants or narcotics-viz, alcohol, opium, or tobacco.”.


Medical Marijuana Laws and Suicide

Medical Marijuana Laws and Suicide
Published in the January, 2015 issue of Research Briefs in Economic Policy is a study on medical marijuana laws and suicide rates. This research suggests the public-health benefits of legaliza­tion may outweigh the costs.