Medical Cannabis Research

Use of Prescription Pain Medications Among Medical Cannabis Patients

Use of Prescription Pain Medications Among Medical Cannabis PatientsIn 2015, researchers at the University of Michigan published the first systematic comparison among medical cannabis users who use and do not use prescription pain medications (PPMs). PPM users and nonusers did not exhibit any difference in either lifetime or past-3-month use of other drugs, including cocaine, sedatives, street opioids, and amphetamines. PPM users rated the efficacy of cannabis higher than PPM for pain management and indicated a strong desire to reduce PPM usage. Longitudinal study designs are needed to better understand the trajectories of alcohol and other drug involvement over time among medical cannabis users. read more…

Use and Effects of Cannabinoids in Military Veterans with PTSD

Use and Effects of Cannabinoids in Military Veterans with PTSD In the United States, post traumatic stress disorder (PTSD) is diagnosed in approximately 5.2 million people annually, and these people suffer a wide range of symptoms. A comprehensive literature search on PTSD and cannabis covering the period January 1, 1995, to October 1, 2014 was conducted. While further research into cannabinoid treatment effects on PTSD symptoms is required, the evaluated evidence indicates that substantial numbers of military veterans with PTSD use cannabis or derivative products to control PTSD symptoms, with some patients reporting benefits in terms of reduced anxiety and insomnia and improved coping ability. read more…

Treating Adult ADHD with Cannabis

Treating Adult ADHD with CannabisThe medical certificates of 30 patients with adult ADHD, who were granted approval by the German Health Ministry to use cannabis flowers between 2012 and 2014, were analysed with regard to course of disease, previous treatment efforts, and effects of self-medication with cannabis or therapy with cannabis-based medications. For adult patients with ADHD, who experience side effects or do not profit from standard medication, cannabis may be an effective and well-tolerated alternative. read more…

Cannabinoids and Liver Cancer

Cannabinoids and Liver CancerHepatocellular carcinoma (HCC) is the leading cause of cancer‐associated mortality worldwide; however, only limited therapeutic treatments are currently available. The present study aimed to investigate the effects of cannabinoids as novel therapeutic targets in HCC. In addition, the mechanism underlying the effects of a synthetic cannabinoid, WIN55, 212‐2, on the BEL7402 HCC cell line was investigated. These results provided a basis for the application of WIN in the treatment of HCC. read more…

Cannabinoids and Epilepsy

Cannabinoids and EpilepsyA study recently published in Neurotherapeutics by researchers at the New York University School of Medicine reviews scientific evidence from pre-clinical and clinical trials of cannabinoids in epilepsy. These studies suggest that CBD avoids the psychoactive effects of the endocannabinoid system to provide a well-tolerated, promising therapeutic for the treatment of seizures. Future placebo-controlled clinical trials will provide insight into cannabinoid function and the potential neuroprotective effects of the endocannabinoid system. read more…

Marijuana Use in Epilepsy: The Myth and the Reality

Marijuana Use in Epilepsy: The Myth and the RealityResearchers at Yale University published this review in Current Neurology and Neuroscience Reports in 2015 with the goal of addressing the most important questions a clinician may have regarding the use of marijuana in epilepsy. They review data for the anticonvulsant properties of the different cannabinoids, mainly tetrahydrocannabinol (THC) and cannabidiol (CBD) and explore the safety data from animal and human studies. read more…

THC Inhibits Replication of Herpesviruses in Vitro

THC Inhibits Replication Of Herpes Viruses In VitroResearchers at the University of South Florida published an article in BioMed Central in 2004 summarizing the antiviral effects of THC and comparing THC with well-characterized antiviral drugs. They compiled data from the literature as well as from their own experimental results. The authors’ observations suggest that THC either directly or indirectly targets a viral gene shared by the herpesviruses. read more…

Cannabinoid Hyperemesis Syndrome: An Under-Recognized Diagnosis

Cannabinoid Hyperemesis Syndrome: An Under-Recognized DiagnosisWith the growing spread of cannabis abuse, a novel clinical disorder has emerged, termed Cannabinoid Hyperemesis Syndrome (CHS). Researchers in Israel published a Case Communications report in the Israel Medical Association Journal in May 2015. The majority of patients with CHS are heavy users of cannabinoids, on a daily or almost daily basis for years. Symptoms are characterized by recurrent attacks of severe nausea and vomiting and accompanying abdominal pain. read more…

PTSD Patients Evaluated for New Mexico Medical Cannabis Program

PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis ProgramThis study reported and statistically analyzed psychometric data on PTSD symptoms collected during 80 psychiatric evaluations of patients applying to the New Mexico Medical Cannabis Program from 2009 to 2011. Greater than 75% reduction in CAPS symptom scores were reported when patients were using cannabis compared to when they were not. read more…

Treatment of Crohn’s Disease with Cannabis

Treatment of Crohn’s Disease with Cannabis: an Observational StudyIn 2011, researchers in Israel published the first study evaluating the effect of cannabis on patients with Crohn’s disease. All patients stated that consuming cannabis had a positive effect, ameliorating disease activity and reducing the need for other conventional medications. The researchers hypothesized that the observed beneficial effect in this study may be due to the anti-inflammatory properties of cannabis, but additional effects of cannabinoids may also play a role. read more…

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