role-of-cannabinoids-in-paiThis 2013 literature review from the American Academy of Pain Medicine by Drs. Ethan Russo & Andrea Hohmann describes the method of action by which cannabinoids alleviate pain, including direct analgesic and anti-inflammatory effects and interactions with endogenous and administered opioids, and explores clinical trials that suggest the utility of cannabinoid medicine as a pain treatment.

Russo-Hohmann-Role-of-Cannabinoids-in-Pain-Management-from-Deer-2013