Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells

Cannabidiol Induces Programmed Cell Death in Breast Cancer CellsA study by researchers at Harvard Medical School was published in Molecular Cancer Therapeutics in 2011 characterizing the mechanism underlying the antitumoral properties of cannabidiol (CBD). This study showed that CBD induced both apoptosis and autophagy-induced death in breast cancer cells and inhibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell lines. These data enhance the desirability of CBD as an anticancer agent, because they suggest that CBD preferentially kills breast cancer cells, while minimizing damage to normal breast tissue. (more…)

Anandamide Inhibits Breast Tumor-Induced Angiogenesis

Anandamide Inhibits Breast Tumor-Induced AngiogenesisEndocannabinoid Anandamide and Breast Cancer – more evidence. This 2014 study out of Italy, published in the journal Translational Medicine, found that following anandamide treatment, MDA-MB-231 cells lose their ability to stimulate endothelial cells proliferation in vitro, due to a significant inhibition of all the pro-angiogenic factors produced by these cells. This finding adds another piece of evidence to the anti-tumor efficacy of anandamide in breast cancer. (more…)

THC Reduces Human Breast Cancer Cell Proliferation

THC Reduces Human Breast Cancer Cell Proliferation THC and breast cancer – Little is known about the effect of cannabinoids on the cell cycle, the main process controlling cell fate. This study out of Spain, published in a 2006 issue of Cancer Research, shows that Δ9-tetrahydrocannabinol (THC), through activation of CB2 cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis
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