Endocannabinoid Signaling in Autism

Endocannabinoid Signaling in AutismIn July 2015, Neurotherapeutics published an article about Autism spectrum disorder (ASD), presenting a modern view of the endocannabinoid (eCB) system, and alterations of its main components in human patients and animal models relevant to ASD. Our understanding of eCB signaling in autism is still in its infancy compared with other disorders of the central nervous system or of peripheral tissues, where eCB-based therapies have already reached preclinical and clinical phases. However, research in this field is rapidly evolving, and novel drugs able to hit specifically a distinct element of the eCB system are being developed at a surprising speed. (more…)

12 Credit Clinical Cannabinoid Medicine Curriculum

SCC, in collaboration with The Medical Cannabis Institute, launches the first online, medical cannabis curriculum that presents, in sequential order, a series of 12 courses designed to take a practicing clinician from the basics of the plant, its history and the underlying physiologic (endocannabinoid) system to the pharmacology and clinical practice of medical cannabis. Healthcare professionals can claim up to 12 CME credits (AMA PRA Category 1 Credit™), receiving a certificate of competency in clinical cannabinoid medicine upon curriculum completionLearn More

The Endocannabinoid System and Brain Aging

The Endocannabinoid System and Brain Aging
Published in 2012, this study concluded that elevation of cannabinoid receptor activity either by pharmacological blockade of the degradation of cannabinoids or by receptor agonists could be a promising strategy for slowing down the progression of brain aging and for alleviating the symptoms of neurodegenerative disorders.

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Osteoarthritis Pain And Cannabinoids

Osteorthritis Pain And CannabinoidsOsteoarthritis and cannabis – Information comes from scientists in the UK and USA, published in PLOS ONE in 2013. Osteoarthritis pain is challenging to treat, with chronic pain leading to central sensitization. Cannabinoids can help. This data provides new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits central sensitization and its contribution to the manifestation of chronic OA pain. These findings suggest that targeting CB2 receptors may have therapeutic potential for treating OA pain.

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