The endocannabinoid system in normal and pathological brain ageing.

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Authors: Andras Bilkei-Gorzo
Philosophical Transactions of the Royal Society B: Biological Sciences, 5 December 2012
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The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and intensively studied. However, endocannabinoids also influence neuronal activity by exerting neuroprotective effects and regulating glial responses. This review centres around this less-s…

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Lower levels of cannabinoid 1 receptor mRNA in female eating disorder patients: association with wrist cutting as impulsive self-injurious behavior.

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Authors: Marc Schroeder, Christian Eberlein, Martina de Zwaan, Johannes Kornhuber, Stefan Bleich, Helge Frieling
Psychoneuroendocrinology, December 2012
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The cannabinoid 1 (CB 1) receptor as the primary mediator of the endocannabinoid (EC) system was found to play a role in eating disorders (EDs), depression, anxiety, and suicidal behavior. The CB 1 receptor is assumed to play a crucial role in the central reward circuitry with…

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The molecular connections between the cannabinoid system and endometriosis.

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Authors: A.M. Sanchez, P. Vigano, A. Mugione, P. Panina-Bordignon, M. Candiani
Molecular Human Reproduction, December 2012
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The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid 1 (CB1) and 2 (CB2) receptors. Alterations of this system have been described in almost every category of disease. These changes can be protective or maladaptive…

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