Cannabinoids in late‐onset Alzheimer’s disease

Authors: AIA Ahmed, MA van der Marck, GAH van den Elsen, MGM Olde Rikkert
Clinical Pharmacology & Therapeutics, 8 March 2015

Given the lack of effective treatments for late-onset Alzheimer’s disease (LOAD) and the substantial burden on patients, families, health care systems, and economies, finding an effective therapy is one of the highest medical priorities. The past few years have seen a growing…

Cannabis sativa: the unconventional “weed” allergen.

Authors: Thad L. Ocampo, Tonya S. Rans
Annals of Allergy, Asthma & Immunology, March 2015

Passage of legislation in Washington, Colorado, Oregon, Alaska, and the District of Columbia allowing recreational use of marijuana, despite federal regulation to the contrary, highlights the continued debate surrounding this unconventional plant. Allergies to marijuana are no…

Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study.

Authors: Marta Di Forti, Arianna Marconi, Elena Carra, Sara Fraietta, Antonella Trotta, Matteo Bonomo, et al
The Lancet Psychiatry, March 2015

BACKGROUND: The risk of individuals having adverse effects from drug use (eg, alcohol) generally depends on the frequency of use and potency of the drug used. We aimed to investigate how frequent use of skunk-like (high-potency) cannabis in south London affected the associatio…

Synthetic and natural cannabinoids: the cardiovascular risk.

Authors: Ethan B. Russo
The British Journal of Cardiology, March 2015

Cannabis has been employed medicinally and recreationally for thousands of years, but it was not until the 1960s that the structure and pharmacology of its primary phytocannabinoid components, cannabidiol (CBD) and tetrahydrocannabinol (THC) were identified, and another genera…

The impact of marijuana policies on youth: clinical, research, and legal update.

Authors: COMMITTEE ON SUBSTANCE ABUSE, COMMITTEE ON ADOLESCENCE
Pediatrics, March 2015

This policy statement is an update of the American Academy of Pediatrics policy statement “Legalization of Marijuana: Potential Impact on Youth,” published in 2004. Pediatricians have special expertise in the care of children and adolescents and may be called on to advise legi…