Long-term safety and efficacy of add-on cannabidiol in patients with Lennox–Gastaut syndrome: Results of a long-term open-label extension trial

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Lennox–Gastaut syndrome (LGS) is an epileptic encephalopathy that is often treatment resistant. Efficacy and safety of add-on cannabidiol (CBD) to treat seizures associated with LGS was demonstrated in two randomized controlled trials (RCTs). Patients who completed the RCTs were invited to enroll in this long-term open-label extension (OLE) trial, GWPCARE5 (NCT02224573). We present the final analysis of safety and efficacy outcomes from GWPCARE5.

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Cuando el conocimiento empírico indígena se encuentra con la ciencia del cannabis

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Dr. Yesid Ramirez creó un programa intensivo gratuito de un día de duración en la Universidad ICESI de Cali (Colombia) para miembros de comunidades indígenas históricamente discriminadas.

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Cannabinoids in the landscape of cancer

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Cannabinoids are a group of terpenophenolic compounds derived from the Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal studies in support of cannabinoids possessing anticancer properties.

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Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa

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Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China.

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The impact of cannabis use on male sexual function: A 10-year, single-center experience

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Despite increasing consumption rates in much of the world, the impact of cannabis use on various components of male sexual function remain poorly established. The purpose of this study was to further evaluate the relationship between cannabis use and reproductive and sexual function using a large patient cohort from a single academic andrology clinic.

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Indigenous Empirical Plant Knowledge Meets Cannabis Science

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Dr. Yesid Ramirez created a free, day-long intensive program on cannabis science at ICESI University in Cali, Colombia for historically discriminated indigenous groups.

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The dose-dependent analgesic effects, abuse liability, safety and tolerability of oral cannabidiol in healthy humans

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Preclinical studies demonstrate that cannabidiol (CBD) elicits an antinociceptive response in animal models of neuropathic pain; in humans, limited data are available to support such analgesic effects. Few studies have examined CBD’s analgesic effects when administered without other compounds, and little is known regarding dose-dependent effects in non-cannabis users.

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Spiritual Benefit from Cannabis

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Like many mind-altering plants, cannabis has been part of spiritual practices for thousands of years. It has deep roots in Hinduism, Islam, Rastafarianism, and indigenous traditions in Asia, Africa, and elsewhere. Yet almost no attention has been given to how contemporary adults employ it spiritually. A sample of 1087 participants (mean age = 38.9) completed an online survey assessing their use of cannabis and other substances, as well as spiritual and psychological characteristics.

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Residual effects of cannabis-use on neuropsychological functioning

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Non-acute effects of cannabis on neurocognition in adolescents remain unclear with most studies being cross-sectional. Therefore, the aim of this longitudinal, multi-center study was to examine the effects of cannabis use on cognitive abilities in participants emerging into adulthood.

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Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation

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Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cy- clic vomiting, abdominal pain, and hot bathing behavior associated with ongoing tetrahydrocannabinol (THC) exposure. Increasing cannabis use may elevate CHS prevalence, exacerbating a public health issue with atten- dant costs and morbidity.

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Dr. Dustin Sulak’s New Book: “Handbook of Cannabis for Clinicians”

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Congrats to SCC Board Member Dustin Sulak, DO who recently published the first foundational text on the clinical use of cannabis and cannabinoid therapies.

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cAMP Signaling–Mediated Phosphorylation of Diacylglycerol Lipase α Regulates Interaction With Ankyrin-G and Dendritic Spine Morphology

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Diacylglycerol lipase α (DAGLα), a major biosynthetic enzyme for endogenous cannabinoid signaling, has emerged as a risk gene in multiple psychiatric disorders. However, its role in the regulation of dendritic spine plasticity is unclear.

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