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The impact of cocaine and marijuana use on low birth weight and preterm birth: a multicenter study.
Authors: Patricia H. Shiono, Mark A. Klebanoff, Robert P. Nugent, Mary Frances Cotch, et al
American Journal of Obstetrics and Gynecology, January 1995
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OBJECTIVE: Our aim was to evaluate prospectively the effects of cocaine and marijuana use on pregnancy outcomes. STUDY DESIGN: A prospective multicenter cohort study was conducted at seven university-based prenatal clinics in the United States from 1984 to 1989. The cohort des…
Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study.
Authors: Melanie C. Dreher, Kevin Nugent, Rebekah Hudgins
Pediatrics, February 1994
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OBJECTIVE: To identify neurobehavioral effects of prenatal marijuana exposure on neonates in rural Jamaica. DESIGN: Ethnographic field studies and standardized neuro-behavior assessments during the neonatal period. SETTING: Rural Jamaica in heavy-marijuana-using population. PA…
Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy.
Authors: Jill S. Hayes, R Lampart, Melanie C Dreher, Lisa Morgan
The West Indian medical journal, September 1991
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This research provides data on the development of 59 Jamaican children, from birth to age 5 years, whose mothers used marijuana during pregnancy. Approximately one-half of the sample used marijuana during pregnancy and were matched with non-users according to age, parity, and…
Maternal marijuana use during lactation and infant development at one year.
Authors: Susan J. Astley, Ruth E. Little
Neurotoxicology and teratology, March-April 1990
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Prenatal marijuana exposure is associated with adverse perinatal effects. Very little is known about the effect of postnatal marijuana exposure on infant development. Postnatal exposure can result from maternal use of marijuana during lactation. Delta-9-tetrahydrocannabinol (T…
Cannabinoid receptor localization in brain
Authors: M Herkenham, A B Lynn, M D Little, M R Johnson, L S Melvin, B R de Costa, K C Rice
Proceedings of the National Academy of Sciences, March 1990
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[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor in brain sections. The potencies of a series of natural and synthetic cannabi…
Poor and pregnant: perinatal ganja use in rural Jamaica.
Authors: Melanie C. Dreher
Advances in Alcohol & Substance Abuse, 1989
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This paper reports the ethnographic findings from a study of cannabis use by pregnant women in rural Jamaica. The perceived functions of ganja in reducing the physiological symptoms of pregnancy and associated psychological stress are described in relation to the sociocultural…
Pharmacokinetics of cannabidiol in dogs.
Authors: E Samara, M Bialer, R Mechoulam
Drug Metabolism and Disposition: The Biological Fate of Chemicals, May/June 1988
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Cannabidiol (CBD) is one of the major nonpsychoactive cannabinoids produced by Cannabis sativa L. Recent studies have shown that CBD has a high protective index, comparable to that of phenobarbital and phenytoin. Because CBD has been reported to possess both anticonvulsant and…
Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.
Authors: A. W. Zuardi, I. Shirakawa, E. Finkelfarb, I. G. Karniol
Psychopharmacology, DATE
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The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements an…
Hypnotic and antiepileptic effects of cannabidiol.
Authors: Elisaldo A. Carlini, Jomar M. Cunha
The Journal of Clinical Pharmacology, August-September 1981
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Clinical trials with cannabidiol (CBD) in healthy volunteers, isomniacs, and epileptic patients conducted in the authors’ laboratory from 1972 up to the present are reviewed. Acute doses of cannabidiol ranging from 10 to 600 mg and chronic administration of 10 mg for 20 days o…
Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
Authors: Jomar M. Cunha, E.A. Carlini, Aparecido E. Pereira, Oswaldo L. Ramos, Camilo Pimentel, et al
Pharmacology, 1980
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In phase 1 of the study, 3 mg/kg daily of cannabidiol (CBD) was given for 30 days to 8 health human volunteers. Another 8 volunteers received the same number of identical capsules containing glucose as placebo in a double-blind setting. Neurological and physical examinations…
Pharmacokinetics of delta9-tetrahydrocannabinol in dogs.
Authors: Edward R. Garrett, Edward R. Garrett, C. Anthony Hunt
Journal of Pharmaceutical Sciences, March 1977
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The pharmacokinetics of intravenously administered 14C-delta9-tetrahydrocannabinol and derived radiolabeled metabolites were studied in three dogs at two doses each at 0.1 or 0.5 and 2.0 mg/kg. Two dogs were biliary cannulated; total bile was collected in one and sampled in th…
Antitussive activity of some naturally occurring cannabinoids in anesthetized cats.
Authors: Robert Gordon, Robert J.Gordon, R.Duane Sofia
European Journal of Pharmacology, February 1976
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Experimental cough was elicited in pentobarbital-anesthetized cats by either electrical stimulation of the superior laryngeal nerve or by mechanical stimulation of the tracheal mucosa. Intravenous administration of delta9-tetrahydrocannabinol (THC) effectively reduced the ampl…