Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.

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Authors: Ethan B. Russo
Cannabis and Cannabinoid Research, 1 July 2016
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Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain treatment resistant. Foremost among these are migraine, fibromyalgia, and irritable bowel syndrome, disorders that may overlap in their affected p…

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Cannabinoids and autoimmune diseases: A systematic review

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Authors: Valeria Katchan, Paula David, Yehuda Shoenfeld
Autoimmunity Reviews, June 2016
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Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2 receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine release. Current research in the role of cannabinoids in the immune system shows that they possess…

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A collaboration investigating endocannabinoid signalling in brain and bone.

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Authors: Andreas Zimmer
Journal of Basic and Clinical Physiology and Pharmacology, 1 May 2016
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Investigations into the cellular and molecular mechanisms underlying the psychoactive effects of cannabis preparations have led to the discovery of the endocannabinoid system. Interest in the central nervous system effects was initially the main focus of the research, but it s…

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Using Medical Cannabis in an Oncology Practice

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Authors: Donald I. Abrams
Oncology, May 2016
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As oncologists, we treat patients who have devastating diagnoses with potent therapies. Hence, we demand solid evidence before recommending any intervention. Unfortunately, when it comes to supporting the use of cannabis in clinical situations, we are frustrated by a dearth of…

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Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview.

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Authors: Rosaliana Libro, Sabrina Giacoppo, Thangavelu Soundara Rajan, Placido Bramanti, Emanuela Mazzon
Molecules, 21 April 2016
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The word dementia describes a class of heterogeneous diseases which etiopathogenetic mechanisms are not well understood. There are different types of dementia, among which, Alzheimer’s disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB) and frontotemporal de…

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Attitudes of Israeli Rheumatologists to the Use of Medical Cannabis as Therapy for Rheumatic Disorders.

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Authors: Jacob N. Ablin, Ori Elkayam, and Mary-Ann Fitzcharles
Rambam Maimonides Medical Journal, 19 April 2016
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BACKGROUND: While medical cannabis has been used for thousands of years in the treatment of pain and other symptoms, evidence-based use is limited and practitioners face multiple areas of uncertainty regarding the rational use of these compounds. Nonetheless, an increasing pub…

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Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis

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Authors: J K L Gunn, C B Rosales, K E Center, A Nuñez, S J Gibson, C Christ, J E Ehiri
BMJ Open, 5 April 2016
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Objective: To assess the effects of use of cannabis during pregnancy on maternal and fetal outcomes. Data sources: 7 electronic databases were searched from inception to 1 April 2014. Studies that investigated the effects of use of cannabis during pregnancy on maternal and fet…

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The impact of ADHD persistence, recent cannabis use, and age of regular cannabis use onset on subcortical volume and cortical thickness in young adults.

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Authors: Krista M. Lisdahl, Leanne Tamm, Jeffery N. Epstein, Terry Jernigan, Brooke S. G. Molina, et al
Drug and Alcohol Dependence, 1 April 2016
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BACKGROUND: Both Attention Deficit Hyperactivity Disorder (ADHD) and chronic cannabis (CAN) use have been associated with brain structural abnormalities, although little is known about the effects of both in young adults. METHODS: Participants included: those with a childho…

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Editorial: Lung macrophages high on cannabinoids: jamming PAMs and taming TAMs?

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Authors: Jürg Gertsch
Journal of Leukocyte Biology, April 2016
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Discussion of cannabinoid receptors and the ECS in macrophage activation.

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Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.

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Authors: Orrin Devinsky, Eric Marsh, Daniel Friedman, Elizabeth Thiele, Linda Laux, et al
The Lancet Neurology, March 2016
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BACKGROUND: Almost a third of patients with epilepsy have a treatment-resistant form, which is associated with severe morbidity and increased mortality. Cannabis-based treatments for epilepsy have generated much interest, but scientific data are scarce. We aimed to establish w…

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In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma.

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Authors: T. Fisher, H. Golan, G. Schiby, S. PriChen, R. Smoum, I. Moshe, N. Peshes-Yaloz, et al
Current Oncology, March 2016
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BACKGROUND: Neuroblastoma (nbl) is one of the most common solid cancers in children. Prognosis in advanced nbl is still poor despite aggressive multimodality therapy. Furthermore, survivors experience severe long-term multi-organ sequelae. Hence, the identification of new ther…

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Integrating cannabis into clinical cancer care.

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Authors: D.I. Abrams
Current Oncology, March 2016
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Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are making it possible for patients to obtain the botanical for medicinal use. For t…

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