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Targeting endocannabinoid signaling in tumor‐associated macrophages as treatment for glioblastoma multiforme
Authors: Susan Fung, Nephi Stella
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 21 January 2014
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Glioblastoma multiforme (GBM) is the most common form of primary brain tumor and is diagnosed in approximately 15,000 people each year in the United States alone. No cure for this type of cancer exists, and the current standard of care treatments provide little benefit and are…
A controlled family study of cannabis users with and without psychosis.
Authors: Ashley C. Proal, Jerry Fleming, Juan A. Galvez-Buccollini, Lynn E. DeLisi
Schizophrenia Research, January 2014
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BACKGROUND: Cannabis is one of the most highly abused illicit drugs in the world. Several studies suggest a link between adolescent cannabis use and schizophrenia. An understanding of this link would have significant implications for legalization of cannabis and its medicinal…
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.
Authors: Carol A. Mathews, Jeremiah M. Scharf, Laura L. Miller, Corrie Macdonald-Wallis, et al
British Journal of Psychiatry, January 2014
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BACKGROUND: Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent. AIMS:
To examine the association between pre- and perinatal e…
Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence.
Authors: Wilfrid Noel Raby, Kenneth M. Carpenter, Jami Rothenberg, Adam C. Brooks, Huiping Jiang, et al
American Journal on Addictions, July/August 2009
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Naltrexone is a theoretically promising alternative to agonist substitution treatment for opioid dependence, but its effectiveness has been severely limited by poor adherence. This study examined, in an independent sample, a previously observed association between moderate can…
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder.
Authors: Felix K Gesell, Alexander A Zoerner, Christina Brauer, Stefan Engeli, Dimitros Tsikas, Andrea Tipold
BMC Veterinary Research, 26 December 2013
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BACKGROUND: Epilepsy is one of the most common chronic neurological disorders in dogs characterized by recurrent seizures. The endocannabinoid (EC) system plays a central role in suppressing pathologic neuronal excitability and in controlling the spread of activity in an epile…
Cannabis finds its way into treatment of Crohn’s disease.
Authors: Rudolf Schicho, Martin Storr
Pharmacology, 2014
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In ancient medicine, cannabis has been widely used to cure disturbances and inflammation of the bowel. A recent clinical study now shows that the medicinal plant Cannabis sativa has lived up to expectations and proved to be highly efficient in cases of inflammatory bowel disea…
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.
Authors: Brenda E. Porter, Catherine Jacobson
Epilepsy & Behavior, December 2013
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Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek alternative treatments. This survey explored the use of cannabidiol-enriched cannabis in ch…
Primary gliosarcoma of the brain: radiologic and histopathologic features.
Authors: Alfredo E. Romero-Rojas, Julio A. Diaz-Perez, Lina M. Ariza-Serrano, et al
The Neuroradiology Journal, December 2013
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Gliosarcoma is a rare central nervous system (CNS) neoplasm with biphasic glial and non-glial malignant components. Here we describe the radiologic and histopathologic features observed in five cases of primary gliosarcoma. The mean age at diagnosis in the studied patients was…
Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint.
Authors: James J. Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, et al
PLoS One, 25 November 2013
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Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processi…
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.
Authors: Dario Siniscalco, Anna Sapone, Catia Giordano, Alessandra Cirillo, Laura de Magistris, et al
Journal of Autism and Developmental Disorders, November 2013
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Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of…
Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study.
Authors: Timna Naftali, Timna Naftali, Lihi Bar-Lev Schleider, Iris Dotan, Ephraim Philip Lansky, et al
Clinical Gastroenterology and Hepatology, October 2013
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BACKGROUND & AIMS: The marijuana plant Cannabis sativa has been reported to produce beneficial effects for patients with inflammatory bowel diseases, but this has not been investigated in controlled trials. We performed a prospective trial to determine whether cannabis can ind…
Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.
Authors: Katherine Ann Scott, Sini Shah, Angus George Dalgleish, Wai Man Liu
Anticancer Research, October 2013
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Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous ar…