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Epigenetic control of skin differentiation genes by phytocannabinoids.
Authors: Mariangela Pucci, Cinzia Rapino, Andrea Di Francesco, Enrico Dainese, et al
British Journal of Pharmacology, October 2013
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BACKGROUND AND PURPOSE: Endocannabinoid signalling has been shown to have a role in the control of epidermal physiology, whereby anandamide is able to regulate the expression of skin differentiation genes through DNA methylation. Here, we investigated the possible epigenetic r…
Pregnancy, breast-feeding, and marijuana: a review article.
Authors: Meg Hill, Kathryn Reed
Obstetrical & Gynecological Survey, October 2013
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Marijuana is a commonly used drug. At present, it remains an illegal substance in most areas of the United States. Recent controversy regarding the perceived harms of this drug has resulted in debate in both legal and medical circles. This review examines evidence regarding th…
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.
Authors: A Neumeister, M D Normandin, R H Pietrzak, D Piomelli, M Q Zheng, A Gujarro-Anton, et al
Molecular Psychiatry, September 2013
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Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using posit…
Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers.
Authors: Ziva D. Cooper, Sandra D. Comer, Margaret Haney
Neuropsychopharmacology, September 2013
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Recent studies have demonstrated the therapeutic potential of cannabinoids to treat pain, yet none have compared the analgesic effectiveness of smoked marijuana to orally administered Δ(9)-tetrahydrocannabinol (THC; dronabinol). This randomized, placebo-controlled, double-dumm…
The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD).
Post-traumatic stress disorder (PTSD) is a psychiatric disorder of significant prevalence and morbidity, whose pathogenesis relies on paradoxical changes of emotional memory processing. An ideal treatment would be a drug able to block the pathological over-consolidation and continuous retrieval of the traumatic event, while enhancing its extinction and reducing the anxiety symptoms.
Survey of Psychiatrists On Medical Cannabis
Psychiatric Times invited psychiatrists to complete a survey about medicinal marijuana and didn’t expect nearly 2200 people to complete that survey in just a few days. The results, reported in…
Cannabinoids: well-suited candidates for the treatment of perinatal brain injury.
Authors: David Fernández-López, Ignacio Lizasoain, Maria Ángeles Moro, José Martínez-Orgado
Brain Sciences, 10 July 2013
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Perinatal brain injury can be induced by a number of different damaging events occurring during or shortly after birth, including neonatal asphyxia, neonatal hypoxia-ischemia and stroke-induced focal ischemia. Typical manifestations of these conditions are the presence of glut…
The impact of marijuana use on glucose, insulin, and insulin resistance among US adults.
Authors: Elizabeth A. Penner, Hannah Buettner, Murray A. Mittleman
The American Journal of Medicine, July 2013
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BACKGROUND: There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggestin…
Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells.
Authors: I. Dando, M. Donadelli, C. Costanzo, E. Dalla Pozza, A. D’Alessandro, L. Zolla, M. Palmieri
Cell Death & Disease, 13 June 2013
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The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism of action remains unclear. We used cannabinoids specific for the CB1 (ACPA) and CB2 (GW) receptors and metabolomic analyses to unra…
Effects of marijuana smoking on the lung.
Authors: Donald P. Tashkin
Annals of the American Thoracic Society, June 2013
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Regular smoking of marijuana by itself causes visible and microscopic injury to the large airways that is consistently associated with an increased likelihood of symptoms of chronic bronchitis that subside after cessation of use. On the other hand, habitual use of marijuana al…
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Authors: E Pérez-Gómez, C Andradas, J M Flores, M Quintanilla, J M Paramio, M Guzmán, C Sánchez
Oncogene, 16 May 2013
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G protein-coupled receptors (GPCRs) control crucial physiological processes and their dysfunction contributes to various human diseases, including cancer. The orphan GPCR GPR55 was identified and cloned more than a decade ago, but very little is known about its physio-patholog…
Medical Marijuana Laws, Traffic Fatalities, and Alcohol Consumption
Authors: D. Mark Anderson, Benjamin Hansen, Daniel I. Rees
The Journal of Law and Economics, May 2013
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To date, 19 states have passed medical marijuana laws, yet very little is known about their effects. The current study examines the relationship between the legalization of medical marijuana and traffic fatalities, the leading cause of death among Americans ages 5–34. The firs…