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The psychoactive compound of Cannabis sativa, Δ(9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover.

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Authors: M.A. Costa, B.M. Fonseca, F. Marques, N.A. Teixeira, G. Correia-da-Silva
Toxicology, 6 August 2015
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The noxious effects of cannabis consumption for fertility and pregnancy outcome are recognized for years. Its consumption during gestation is associated with alterations in foetal growth, low birth weight and preterm labor. The main psychoactive molecule of cannabis, Δ(9)-tetr…

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Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells.

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Authors: I. Dando, M. Donadelli, C. Costanzo, E. Dalla Pozza, A. D’Alessandro, L. Zolla, M. Palmieri
Cell Death & Disease, 13 June 2013
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The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism of action remains unclear. We used cannabinoids specific for the CB1 (ACPA) and CB2 (GW) receptors and metabolomic analyses to unra…

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