Cannabidiol A Race To Relief
Authors: Nishi Whiteley and Ethan Russo, MD Published in HerbalGram 2020 Introduction Few chemical compounds have enjoyed such a rapid ascent to market acceptance and consumer popularity as CBD. According…
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Understanding Cannabis-Based Therapeutics in Sports Medicine
SCC Member Gretchen E. Maurer, DO, MS and colleagues examine the current research potential for cannabis in sports medicine.
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.
Free Radical Biology and Medicine, October 2019
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Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in the neonatal period, and disability including cerebral palsy in the long term. The brain injury is secondary to both the hypoxic-ischemic event and the reoxygenation-reperfusion following…
The endocannabinoid system and stroke: A focused review.
Brain Circulation, January-March 2019
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Stroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke pathophysiology, as well as th…
Therapeutic potential of cannabinoids as neuroprotective agents for damaged cells conducing to movement disorders.
International Review of Neurobiology, 2019
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The basal ganglia (BG), an organized network of nuclei that integrates cortical information, play a crucial role in controlling motor function. In fact, movement disorders such as Parkinson’s disease (PD) and Huntington’s disease (HD) are caused by the degeneration of specific…
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age.
Frontiers in Immunology, 21 September 2018
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Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental a…
In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease
Frontiers in Pharmacology, 3 February 2017
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Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and oxidative stress. Current AD treatments do…
Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies.
Methods in Enzymology, 2017
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The increase in lifespan during the last 50 years, mainly in developed countries, has originated a progressive elevation in the incidence of chronic neurodegenerative disorders, for which aging is the key risk factor. This fact will definitively become the major biomedical cha…
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview.
Molecules, 21 April 2016
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The word dementia describes a class of heterogeneous diseases which etiopathogenetic mechanisms are not well understood. There are different types of dementia, among which, Alzheimer’s disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB) and frontotemporal de…
Cannabinoids to treat spinal cord injury.
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 4 January 2016
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Spinal cord injury (SCI) is a devastating condition for which there is no standard treatment beyond rehabilitation strategies. In this review, we discuss the current knowledge on the use of cannabinoids to treat this condition. The endocannabinoid system is expressed in the in…
Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Journal of Neural Transmission, July 2014
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The aim of this study was to characterize the influence of WIN 55,212-2 (WIN–a non-selective cannabinoid CB1 and CB2 receptor agonist) on the anticonvulsant effects of various classical antiepileptic drugs (clobazam, clonazepam, phenobarbital and valproate) in the mouse 6 Hz-…
The endocannabinoid system in normal and pathological brain ageing.
Philosophical Transactions of the Royal Society B: Biological Sciences, 5 December 2012
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The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and intensively studied. However, endocannabinoids also influence neuronal activity by exerting neuroprotective effects and regulating glial responses. This review centres around this less-s…