Drug and Alcohol Dependence, June 2018
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BACKGROUND: We sought to describe the correlates of marijuana use during and after pregnancy, and to examine the independent relationship between prenatal marijuana use and infant outcomes. STUDY DESIGN: We used state-specific data from the Pregnancy Risk Assessment Monitoring…
Obstetrics & Gynecology, May 2018
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OBJECTIVE: To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. METHODS:
In this pilot pharmacokinetic study, breast milk samples were col…
Pharmacology & Therapeutics, February 2018
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The broad-based legalization of cannabis use has created a strong need to understand its impact on human health and behavior. The risks that may be associated with cannabis use, particularly for sensitive subgroups such as pregnant women, are difficult to define because of a p…
American Journal of Obstetrics and Gynecology, August 2017
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To the Editors: We read with interest the article by Chasnoff, 1 which concluded that physicians should be educated about the negative effects of marijuana use during pregnancy and should discourage its use by pregnant women and women considering becoming pregnant. In our view…
Obstetrics & Gynecology, October 2016
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OBJECTIVE: To estimate whether marijuana use in pregnancy increases risks for adverse neonatal outcomes and clarify if any increased risk is attributable to marijuana use itself or to confounding factors such as tobacco use. DATA SOURCES: Two authors performed a search of the…
American Journal of Obstetrics and Gynecology, October 2016
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BACKGROUND: It is generally assumed that marijuana is one of the more widely used controlled substances during pregnancy. However, there remains a general paucity of population-based data regarding its use and subsequent perinatal morbidity. We hypothesized that direct patient…
BMJ Open, 5 April 2016
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Objective: To assess the effects of use of cannabis during pregnancy on maternal and fetal outcomes. Data sources: 7 electronic databases were searched from inception to 1 April 2014. Studies that investigated the effects of use of cannabis during pregnancy on maternal and fet…
Toxicology, 6 August 2015
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The noxious effects of cannabis consumption for fertility and pregnancy outcome are recognized for years. Its consumption during gestation is associated with alterations in foetal growth, low birth weight and preterm labor. The main psychoactive molecule of cannabis, Δ(9)-tetr…
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 3 July 2014
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Accumulating evidence from both human and preclinical studies indicates maternal substance use during pregnancy can affect fetal development, birth weight and infant outcomes. Thus, the prenatal period can be regarded as an important and potentially sensitive period of develop…
British Journal of Psychiatry, January 2014
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BACKGROUND: Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent. AIMS:
To examine the association between pre- and perinatal e…
Pediatrics, March 2013
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Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician’s role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition…
Journal of Psychopharmacology, October 2012
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In the United States, marijuana is one of the drugs most abused by adolescents, with females representing a growing number of users. In previous studies, treatment of adolescent female rats with morphine significantly altered brain reward systems in future offspring. As both c…