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Cannabis for chronic pain: cardiovascular safety in a nationwide Danish study

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A rising number of countries allow physicians to treat chronic pain with medical cannabis. However, recreational cannabis use has been linked with cardiovascular side effects, necessitating investigations concerning the safety of prescribed medical cannabis. Using nationwide Danish registers, patients with chronic pain initiating first-time treatment with medical cannabis during 2018–21 were identified and matched 1:5 to corresponding control patients on age, sex, chronic pain diagnosis, and concomitant use of other pain medication. The absolute risks of first-time arrhythmia (atrial fibrillation/flutter, conduction disorders, paroxysmal tachycardias, and ventricular arrhythmias) and acute coronary syndrome were reported comparing medical cannabis use with no use.

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Cannabis and adverse cardiovascular events: A systematic review and meta-analysis of observational studies

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Cannabis is the most used illicit drug in the world. Global trends of decriminalization and legali- zation of cannabis lead to various forms of cannabis use and bring great concerns over adverse events, partic- ularly in the cardiovascular (CV) system. To date, the association between cannabis and adverse CV events is still controversial. We aim to conduct a systematic review and meta-analysis to assess the adverse CV events from cannabis use.

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Association Between Recent Cannabinoid Use and Acute Ischemic Stroke

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Author: Carmela V. San Luis, Christa O’Hana S. Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J. Villareal, Tapan Mehta, Shreyas Gangadhara Published in Frontiers in Psychology June 2020 Abstract Objectives Studies that…

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The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review.

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Authors: Mellar P. Davis, Bertrand Behm, Zankhana Mehta, Carlos Fernandez
American Journal of Hospice and Palliative Medicine, December 2019
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Palmitoylethanolamide (PEA) is a nutraceutical endocannabinoid that was retrospectively discovered in egg yolks. Feeding poor children with known streptococcal infections prevented rheumatic fever. Subsequently, it was found to alter the course of influenza. Unfortunately, the…

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Cannabis use predicts risks of heart failure and cerebrovascular accidents: results from the National Inpatient Sample.

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Authors: Aditi Kalla, Parasuram Krishnamoorthy, Akshaya Gopalakrishnan, Vincent Figueredo
Journal of Cardiovascular Medicine, September 2018
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BACKGROUND: Cannabis for medicinal and/or recreational purposes has been decriminalized in 28 states as of the 2016 election. In the remaining states, cannabis remains the most commonly used illicit drug. Cardiovascular effects of cannabis use are not well established due to a…

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Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke.

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Authors: Isabel Bravo-Ferrer, María I. Cuartero , Juan G. Zarruk, Jesús M. Pradillo, Olivia Hurtado, et al
Stroke, January 2017
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BACKGROUND AND PURPOSE: Stroke is a leading cause of adult disability characterized by physical, cognitive, and emotional disturbances. Unfortunately, pharmacological options are scarce. The cannabinoid type-2 receptor (CB2R) is neuroprotective in acute experimental stroke by …

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